(012) 420-2075
microscopy-society-of-southern-africa-platelet
microscopy-society-of-southern-africa-platelet
microscopy-society-of-southern-africa-platelet
microscopy-society-of-southern-africa-platelet
microscopy-society-of-southern-africa-platelet

FEEDBACK FROM THE WINNER OF THE ALS/JEOL MOST PROMISING MICROSCOPIST AWARD 2016

BY MSSA

I am Genevéve Marx and currently a 2nd year PhD student at the Centre for HRTEM at Nelson Mandela University (NMU), Port Elizabeth. The supervisors of my PhD project are Dr Johan Westraadt and Prof Jan Neethling. The title of my PhD project is “Microstructural Evolution of Welded Creep Aged CSEF Steel” and it entails the quantitative measuring of the microstructure of creep strength enhanced ferritic (CSEF) steels that have been in use in coal-fired power plants and welded on. These results is used as input into creep models that can be implemented to predict more accurately the remaining life of the power plant components made of these steels.
What an honor it was to win the prestigious ALS/JEOL award for the “Most Promising Microscopist” at the 54th Annual Microscopy Society of Southern Africa (MSSA 2016) conference held in Port Elizabeth...


Read full article

read more...
 September 12, 2017
Comments (0)
General

Students from the University of Stellenbosch win prizes at the national microscopy conference, Dec 2016

BY MSSA

At the recent microscopy conference, hosted by the Microscopy Society of Southern Africa (MSSA) in Port Elisabeth in Dec 2016, three SU students from the Department of Physiological Sciences won prizes for their research performed. Innovative microscopy techniques were implemented to unravel research questions around Alzheimer’s disease and neuronal cell death as well as brain cancer. Dumisile Lumkwana received the ‘Wirsam Light Microscopy Prize - Best presentation’ for presenting data of her PhD work, Jurgen Kriel was awarded the Wirsam Scientific Prize - Best Student Paper Life Sciences’ for his MSc research and Yigael Powrie received the ‘SA Scientific Award – Best Presentation Confocal Microscopy’ for his MSc work.
 
‘This is a wonderful achievement and testimony for the excellent and hard  work, a happy moment for me’, said their supervisor Dr Ben Loos, who heads up the Neuro-Research Group at the department of Physiological Sciences, Stellenbosch University.

read more...
 July 05, 2017
Comments (0)
MSSA Newsletter

Investigating the role of rilmenidine and spermidine in an in vitro model of Alzheimer’s disease

BY Dumisile Lumkwana

Modulation of autophagy has been shown to have therapeutic potential for Alzheimer’s disease through favouring the clearance of aggregate prone proteins such as amyloid-? and p-Tau. Recent research has shown that spermidine and rilmenidine have the potential to affect autophagy, but the exact relationship between autophagy, protein clearance and cell death remains unclear. Moreover, the impact of concentration differences on autophagic flux and on subsequent protein clearance and neuronal toxicity is uncertain. Therefore, we aimed to characterize the autophagic profile of rilmenidine and spermidine to assess the degree of protection and protein clearance in a paraquat induced neuronal toxicity model of Alzheimer’s disease.

 
We found that spermidine and rilmenidine modulate autophagic flux in a concentration dependent manner. Both these agents up-regulated autophagy, improved cell viability through clearance of protein aggregates and protected the cells against paraquat induced neuronal toxicity. In addition, spermidine protects against mitochondrial and tubulin network damage. These findings suggest that precision controlled induction of autophagy may be a suitable pharmacological target for preserving neuronal cell viability in Alzheimer’s disease. Future work is required to better quantify autophagic flux.


Stellenbosch University

read more...
 July 05, 2017
Comments (0)
MSSA Newsletter

Mitochondrial Fission and Fusion in Glioma’s – cell death sensitization through autophagy control

BY Jurgen Kriel

The study focussed on the effect that autophagy modulation has on mitochondrial bioenergetics in the context of cancer metabolism, entailing extensive characterisation of mitochondrial dynamics and morphometrics. We developed a unique photoactivation protocol that more accurately determines the rate at which mitochondrial fission and fusion occurs. Image processing algorithms were also constructed in Wolfram Mathematica to better quantify the morphological changes within mitochondrial networks. Correlating these data sets with changes in autophagic flux and mitochondrial respiration, we determined that a state of intermediate connectivity exists in mitochondrial networks when autophagic degradation is impaired. During this maladaptive state, brain cancer cells could be effectively sensitized to undergo cell death, indicating the importance of both autophagic flux and mitochondrial bioenergetics in upholding tumour metabolism. 


Stellenbosch University

read more...
 July 05, 2017
Comments (0)
MSSA Newsletter

Tubulin dysfunction in Alzheimer’s Disease

BY Yigael Powrie

The MSc study entailed investigating the relationship between the neuronal microtubulin cytoskeleton and the protein degradation process called autophagy, a system known to be dysfunctional in Alzheimer’s disease. We sought to elucidate previously unknown molecular events that occur prior to the onset of cell death brought on by induced autophagy dysfunction and in doing so highlight potentially new targets for therapeutic intervention in the treatment of Alzheimer’s disease.

 

Stellenbosch University

 

IMAGE: Micrograph of a mouse brain cell stained with fluorescent antibodies to visualize the microtubulin cytoskeleton (Green), Spastin (Red) - a protein known to interact with microtubulin and the nucleus (Blue).

read more...
 July 05, 2017
Comments (0)
MSSA Newsletter

Feedback from the winner of the ALS/JEOL Most Promising Microscopist Award 2014

BY MSSA

I remember applying to the MSSA conference on the insistence of my supervisor. I was reluctant to attend, since I was only in my honours year and I had never attended a conference before. I presented a poster of my project entitled “Investigating Tau pathology in an in vitro model for Alzheimer’s disease”. The conference was enough of an experience to me alone. So I never thought I would walk away with any award, never mind the top prize of “Most Promising Microscopist”.

 

read more

read more...
 August 19, 2015
Comments (0)
General

Feedback from the winner of the ALS/JEOL Most Promising Microscopist Award 2013

BY MSSA

It was a balmy December night at the MSSA 2013 gala dinner - hosted at the Farm Inn east of Pretoria - when my name was announced as the winner of the JEOL/ALS sponsored: ‘Most promising microscopist award.’ This prize included an all-expenses paid trip to present at an international microscopy conference in 2014. After normalizing my heart rate realising that I had indeed won this coveted prize, I knew that I wanted to attend what I like to refer to as the “Olympics of microscopy” – The International Microscopy Congress (IMC)

 

Read more

read more...
 March 13, 2015
Comments (0)
General

MSSA News Special Edition 2011

BY MSSA

Dear Microscopy Community,


It gives me great pleasure to send this Special Edition of our new electronic MSSA NEWS out to everyone concerned. It is such an exciting time for the entire microscopy community with the launch of the new Centre for High Resolution Transmission Electron Microscopy (CHRTEM) at the Nelson Mandela Metropolitan University. On 11 October, many guests braved the wind and rainy weather in Port Elizabeth for the most important microscopy-related event to date this year! It was a fantastic day with a number of interesting presentations included in the proceedings...

 

Download Newsletter

read more...
 June 09, 2014
Comments (0)
MSSA Newsletter

MSSA News 2012

BY MSSA

Dear Microscopy Community,
The latter part of 2012 has arrived, and I’m sure that the first six months have gone by at a most alarming rate! At the new Centre for High Resolution Electron Microscopy (CHRTEM) at Nelson Mandela Metropolitan University, imaging of single atoms recently caused great excitement when viewed by means of the JEM-ARM 200F launched in October 2011. The involvement of the CHRTEM also with the SA Nanoscience and Nanotechnology Summer School soon after the launch, made the end of the year extremely busy in Port Elizabeth...

 

Download Newsletter

read more...
 June 09, 2014
Comments (0)
MSSA Newsletter

Contact Us

Tel & Address Info

Tel:  012 420 2075

Fax:  012 3625150


Address:
University of Pretoria

Cnr.Lynnwood Road and Roper Street Hatfield South 

Pretoria

0002





Operation Hours:

Monday - Friday 

08h00 - 18h00


Saturdays

08h00 - 13h00